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Mainz is the capital and largest city of Rhineland-Palatinate, Germany. The city is located on the Rhine river at its confluence with the Main river, opposite Wiesbaden on the border with Hesse. Mainz is an independent city with a population of 206,628 and forms part of the Frankfurt Rhine-Main Metropolitan Region.Mainz was founded by the Romans in the 1st century BC during the Classical antiquity era, serving as a military fortress on the northernmost frontier of the Roman Empire and as the provincial capital of Germania Superior.